What do available data tell us about COVID-19 vaccine effectiveness against infection, hospitalization, and death, including during the emergence of new variants like Omicron?
All available data show that mRNA COVID-19 vaccines continue to meet their primary goal: prevention of severe outcomes from COVID-19, including hospitalization and death, among children and adults. Protection against severe disease is highest in those who receive a booster dose.[1,2,3]
Although the level of protection against SARS-CoV-2 infection after COVID-19 vaccination has declined in all ages with the emergence of the Omicron variant, vaccination still reduces the risk for infection and COVID-19–associated hospitalization and death, especially among people who receive a booster dose.
