Invasive Mold in Patients With COVID-19

Invasive Aspergillosis and Mucormycosis in Patients With COVID-19

Dallas Smith, PharmD; Jeremy A. W. Gold, MD, MS

Disclosures

March 03, 2022

Editorial Collaboration

Medscape &

Invasive aspergillosis and mucormycosis are life-threatening infections caused by environmental molds. Invasive aspergillosis most often affects the lungs (pulmonary aspergillosis), while mucormycosis most often affects the sinuses, lungs, or skin.[1] Classic patient risk factors for these conditions include hematologic malignancies, stem cell or solid organ transplantation, and other forms of severe immunosuppression.[2,3] Uncontrolled diabetes is an important risk factor for mucormycosis.[2]

COVID-19 is likely to increase the risk for pulmonary aspergillosis and mucormycosis because of COVID-19–induced immune dysregulation and treatments for COVID-19 (eg, corticosteroids) that weaken host immune defenses against molds. [4,5] COVID-19–associated pulmonary aspergillosis (CAPA) and mucormycosis (CAM) have emerged globally as public health threats during the pandemic

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