Exocrine pancreatic insufficiency (EPI), the inability to digest food due to the lack of digestive enzymes, can result in steatorrhea, nutrient malabsorption, weight loss, bloating, and abdominal pain. Diagnosis can challenge the clinician as the signs and symptoms are similar to those of other gastrointestinal diseases. In addition, management of EPI and the conditions that underlie it continues to evolve. Stay current with the latest diagnostic and treatment recommendations as well as current news on EPI at our special resource center.