Alzheimer Disease Journal Articles

• Inflammation, Aging, and Cardiovascular Disease This review discusses recent advances regarding "inflamm-aging"; that is, age-dependent activation of inflammation and the pathways by which it influences the onset of cardiovascular disease.
  Journal of the American College of Cardiology, May 18, 2022
• Antipsychotics and Mortality Risk in Patients With Dementia This study found a significant increase in 180-day mortality risk in patients with dementia treated with antipsychotic drugs, irrespective of preexisting comorbidities.
  Journal of the American Geriatrics Society, May 10, 2022
• Outcomes of mAb Therapy During a COVID-19 Outbreak in a SNF This study showed that receipt of monoclonal antibody therapy significantly reduced mortality and need for supplemental oxygen in skilled nursing facility residents with mild-to-moderate COVID-19.
  Journal of the American Geriatrics Society, April 26, 2022
• Antipsychotic, Sedative Medications in Older ED Patients What factors are associated with the administration of sedatives and antipsychotics in older patients presenting to the emergency department?
  Journal of the American Geriatrics Society, April 05, 2022
• Evaluation of High-Throughput SARS-CoV-2 Serologic Assays How do the various commercial high-throughput SARS-CoV-2 serologic assays perform, and in what applications could they be of use?
  Emerging Infectious Diseases, March 29, 2022
• Interventions for Frailty Among Older Adults With CVD Review the various definitions of frailty, how frailty can be measured, and interventions to prevent, reverse, or slow the progression of frailty in patients with cardiovascular disease.
  Journal of the American College of Cardiology, March 25, 2022
• FT4, Brain Frailty and Clock Drawing Test in Stroke or TIA A new study examines the possible associations between free thyroxine levels, brain frailty, and clock drawing test performance and their effects on cognitive decline.
  Clinical Endocrinology, March 17, 2022
• Smartphone Technology to Improve Prospective Memory Functioning Are smartphone-based strategies feasible for managing everyday prospective memory tasks in persons with cognitive impairment?
  Journal of the American Geriatrics Society, March 15, 2022
• Evaluating Older Adults With Cognitive Dysfunction This study highlights the challenges of obtaining collateral information from older adults with cognitive dysfunction presenting to the ED. How did the COVID-19 pandemic exacerbate the challenges?
  Journal of the American Geriatrics Society, March 01, 2022
• Neuropsychiatric Manifestations of Thyroid Disease Learn more about the cognitive and psychiatric disorders associated with thyroid dysfunction and the pathophysiology behind these manifestations.
  Journal of the Endocrine Society, March 01, 2022
• Treatment Brings Hope in Alzheimer Disease: Role of Imaging AI How might the approval of Aduhelm and other disease-modifying therapies for the treatment of Alzheimer disease impact the use of AI-assisted brain imaging for screening and evaluation of patients?
  Applied Radiology, February 17, 2022
• Riluzole and Cerebral Glucose Metabolism in Alzheimer Disease This study indicates that the glutamate modulator riluzole slows decline of cerebral glucose metabolism in patients with Alzheimer disease, as measured by FDG-PET. Might it be an effective AD therapy?
  Brain, February 15, 2022
• Mechanisms of Neurological Disorders in COVID-19 This review provides an update on neurological manifestations of COVID-19 and examines what we know regarding the neuropathogenic mechanisms implicated in SARS-CoV-2 infection.
  Brain, February 08, 2022
• Cognitive Performance in Individuals With Atrial Fibrillation Is atrial fibrillation associated with increased risk of cognitive decline?
  Age and Ageing, January 19, 2022
• Mid- to Late-Life Body Mass Index and Dementia Risk Leveraging 38 years of data from the Framingham Offspring study, this study aimed to clarify the complex relationship between BMI, obesity, and risk of dementia at different stages of life.
  American Journal of Epidemiology, December 24, 2021
• Aducanumab and the Certainty of Evidence In this commentary, the authors review the controversial approval of the monoclonal antibody aducanumab as a treatment for dementia.
  Age and Ageing, December 17, 2021
• The Importance of Neuroimaging in Dementia Treatment The approval of aducanumab for Alzheimer disease will increase the need for neuroimaging in these patients. In what ways can neuroimaging improve diagnosis of AD and other neurodegenerative diseases?
  Applied Radiology, November 16, 2021
• Forget Ischemia: It's All About the Plaque Recent studies reinforce the growing consensus that ischemia testing is a suboptimal measure of CAD severity and that CCTA provides superior diagnostic information and risk stratification.
  Circulation, November 04, 2021
• Polypharmacy Among Older Adults With or Without Dementia How prevalent is polypharmacy in older community-dwelling adults with dementia? What are the most common categories of medication being prescribed?
  Journal of the American Geriatrics Society, October 25, 2021
• Barriers to Telehealth Access Among Homebound Older Adults The COVID-19 pandemic substantially increased the need for video-based telehealth use in home-based care. What are the main challenges faced by older homebound patients in accessing telehealth care?
  Journal of the American Geriatrics Society, October 11, 2021