Clostridium difficile Infection News

• Spore Therapy Cuts C. Difficile Reinfection by 68% in 8-Week Study An experimental 3-day therapy that adds Firmicutes spores to the gut can reduce the risk of C. difficile reinfection by 68%, according to the results from an 8-week phase 3 study.
  Reuters Health Information, January 19, 2022
• Antibiotics Plus Oral Fecal Microbiota Transplant Tied to UC Remission In patients with active ulcerative colitis, antibiotics followed by oral lyophilized fecal microbiota transplantation was associated with induction of remission in a small placebo-controlled trial in Australia.
  Reuters Health Information, December 24, 2021
• Donor-Derived Strains Predict FMT Response for Ulcerative Colitis Core strains from human donors limited ulcerative colitis in mouse models, which may shape strategies for more effective microbial therapy.
  Medscape Medical News, December 06, 2021
• 'Forgotten Antibiotic' Better Than Cefotaxime in Febrile UTIs? The rich, commensal microbiota of the distal gut is a breeding ground for resistant microorganisms, and collateral damage to the human microbiota can occur with use of antibiotics.
  Medscape Medical News, November 02, 2021
• ACG 2021 A Pill for C difficile Works by Increasing Microbiome Diversity Freeze-dried human stool may offer advantages for the treatment of C difficile infections.
  Medscape Medical News, October 24, 2021
• Fecal Transplants May Improve Resistance to Melanoma Therapy 'The big question...is why and how does FMT work, and how can we make the response better?' asked Dr Teri Greiling of Oregon Health & Science University.
  Medscape Medical News, October 21, 2021
• Gut Bacteria May Fuel Prostate Cancer Treatment Resistance During prostate cancer treatment, some gut bacteria start making hormones that may support cancer growth and treatment resistance.
  WebMD Health News, October 15, 2021
• Women With Recurrent UTIs Express Fear, Frustration Fear of antibiotic overuse and frustration with practitioners who prescribe them too freely are key sentiments from women with recurrent urinary tract infections.
  Medscape Medical News, October 08, 2021
• IDWeek 2021 Shoe Swabs Find High C. diff Counts Outside Healthcare Sites Clostridioides difficile is most often thought of as a disease acquired in healthcare facilities, but researchers find that shoe bottoms tell another story of transmission in communities.
  Medscape Medical News, October 04, 2021
• To Understand Airborne Transmission of Disease, Follow the Flow Viruses and bacteria travel in fluids, such as the air we breathe. Studying exhalations, toilet flushes, and raindrops can sharpen the big-picture view of how to prevent infections.
  Knowable Magazine, September 07, 2021
• Healthcare-Associated Infections Spiked in 2020 in US Hospitals A CDC analysis found some infections rose nationally by as much as 48% during the COVID-19 pandemic.
  Medscape Medical News, September 02, 2021
• Secondary Oral Vancomycin PPX Reduces Recurrent C Diff Infection Pediatric patients with C difficile infection have a significantly lower risk of recurrence within 8 weeks of antibiotic exposure when they receive secondary oral vancomycin prophylaxis, a small study suggests.
  Reuters Health Information, July 30, 2021
• ECCMID 2021 C Diff Eradication Not Necessary for Clinical Cure The findings support existing guidance not to test for presence of C difficile after treatment if the patient is asymptomatic.
  Medscape Medical News, July 26, 2021
• Fecal Transplantation and Fiber Improves Insulin in Obesity "The potential for improving human health through the microbiome is immense. We are only scratching the surface at the moment," says the lead author of small new study.
  Medscape Medical News, July 14, 2021
• Clostridioides difficile: 2 Sets of Guidelines Disagree Infectious disease and gastroenterology perspectives collide in recommendations for initial and recurrent Clostridioides difficile.
  Medscape Medical News, July 07, 2021
• New Guideline for Prevention, Diagnosis, and Treatment of C diff New guidelines on C difficile from the American College of Gastroenterology offer recommendations on prevention, diagnosis, and treatment, along with guidance for special populations.
  Medscape Medical News, June 24, 2021
• DDW 2021 Microbiome Therapeutic Offers Protection Against Recurrent C diff SER-109, an oral microbiome therapeutic, safely protects against Clostridioides difficile recurrence for up to 24 weeks, according to a recent phase 3 trial.
  Medscape Medical News, May 28, 2021
• SHM 2021 Smart Prescribing Strategies Improve Antibiotic Stewardship Ruling out UTIs and limiting antibiotic duration in pneumonia patients can help reduce resistance and improve outcomes.
  Medscape Medical News, May 14, 2021
• Fecal Transplantation Safe but Ineffective in PsA Trial A trial found fecal microbiota transplantation in psoriatic arthritis inferior to sham but safe, and investigators said it's worthy of future study.
  Medscape Medical News, May 07, 2021
• Fecal Transplant Overcomes Resistance to Immunotherapy Some patients with advanced melanoma who were unresponsive to pembrolizumab showed a response after receiving a fecal transplant.
  Medscape Medical News, February 05, 2021