The study covered in this summary was published in papers.ssrn.com as a preprint and has not yet been peer reviewed.
Key Takeaways
Overall in-hospital mortality for patients with sepsis-induced cardiomyopathy (SIC) trended higher, short of significance, than for patients with sepsis but no related cardiomyopathy in a meta-analysis of studies and systematic review of the literature.
But in-hospital mortality for patients with SIC from 10 days after hospitalization to 1 month was significantly increased, as was 1-month mortality.
One-month mortality in patients with SIC was more strongly associated with right ventricular (RV) dysfunction than with left ventricular (LV) dysfunction.
Why This Matters
The meta-analysis of studies clarifying prognosis after SIC at different hospitalization intervals suggests that the condition can persist as a disease state long after the acute stage, even after discharge, and underscores the importance of extended surveillance and care of such patients.
Given the apparent relevance of RV, as well as LV, dysfunction to prognosis in patients with SIC, assessment of bilateral cardiac function is vital to management.
Study Design
The authors performed a meta-analysis and provide a systematic review of English-language reports published up to July 2021 and catalogued in Embase and PubMed for which mortality in patients with SIC, as opposed to other issues, such as cardiac function, was a main focus.
