People with nonalcoholic fatty liver disease (NAFLD) and a lean or healthy body mass index (BMI) are at increased risk for peripheral vascular disease, stroke, and cardiovascular disease, a surprise finding from a new study reveals.
"Our team had expected to see that those with a normal BMI would have a lower prevalence of any metabolic or cardiovascular conditions," lead researcher Karn Wijarnpreecha, MD, MPH, said during a media briefing that previewed select research for Digestive Disease Week (DDW) 2022. "So, we were very surprised to find this link to cardiovascular disease."
The investigators saw this increased risk of cardiovascular disease despite this group having a lower prevalence of atherosclerotic risk factors and metabolic disease.
This first study of its kind suggests physicians should consider the risk of cardiovascular disease in all patients with NAFLD, not just in those who are overweight or living with obesity — groups traditionally thought to carry more risk.
NAFLD in lean individuals is not a benign disease.
"NAFLD patients with a normal BMI are often overlooked because we assume that the risk for more serious conditions is lower than for those who are overweight or obese. But this way of thinking may be putting these patients at risk," added Wijarnpreecha, who is a transplant hepatology fellow at the University of Michigan in Ann Arbor.
