Herpetic Anterior Uveitis Following Pfizer–BioNTech Coronavirus Disease 2019 Vaccine

Two Case Reports

José Manuel Ortiz-Egea; Cristina Gómez Sánchez; Andrés López-Jiménez; Olga Diego Navarro


J Med Case Reports. 2022;16(127) 

In This Article

Abstract and Introduction


Purpose: To describe two cases of herpetic anterior uveitis after inoculation of the first dose of Pfizer–BioNTech coronavirus disease 2019 vaccine.

Methods: Case 1: a healthy 92-year-old Caucasian woman developed symptomatic unilateral anterior uveitis for 3 days after Pfizer–BioNTech coronavirus disease 2019 vaccination (Pfizer Inc.). The episode fully resolved with topical and oral antiviral treatment. Case 2: a previously healthy 85-year-old Caucasian woman with left hemicranial signs of herpes zoster infection, associated with herpetic keratouveitis for 3 days after Pfizer–BioNTech coronavirus disease 2019 vaccination. Treatment with topical antibiotics and both oral and topical antiherpetic medication was administered, and she recovered successfully in 5 weeks.

Conclusion: Clinicians should be aware of the possibility of eye inflammation in the form of herpetic reactivation after coronavirus disease 2019 vaccination.