Interventions for Basal Cell Carcinoma

Interventions for Basal Cell Carcinoma

Abridged Cochrane Systematic Review and Grade Assessments

J. Thomson; S. Hogan; J. Leonardi-Bee; H. C. Williams; F. J. Bath-Hextall

Disclosures

The British Journal of Dermatology. 2021;185(3):499-511. 

In This Article

Abstract and Introduction

Abstract

Background: Basal cell carcinoma (BCC) is the most common cancer affecting white-skinned individuals, and the worldwide incidence is increasing. Although rarely fatal, BCC is associated with significant morbidity and costs.

Objectives: To assess the effects of interventions for primary BCC in immunocompetent adults.

Methods: We updated our searches of the following databases to November 2019: Cochrane Skin Group Specialised Register, CENTRAL, MEDLINE, Embase, CINAHL and LILACS. Certainty of evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation method. We used standard methodological procedures expected by Cochrane.

Results: We included 52 randomized controlled trials with 6990 participants (median age 65 years; range 20–95). Mean study duration was 13 months (range 6 weeks–10 years). Ninety-two per cent (n= 48/52) of studies exclusively included histologically low-risk BCC (nodular and superficial subtypes). The certainty of evidence was predominantly low or moderate for the outcomes of interest. Overall, surgical interventions have the lowest recurrence rates, and there may be slightly fewer recurrences with Mohs micrographic surgery over surgical excision for primary, facial BCC (high-risk histological subtype or located in the 'H-zone' or both) (low-certainty evidence). Nonsurgical treatments, when used for low-risk BCC, are less effective than surgical treatments, but recurrence rates are acceptable and cosmetic outcomes are probably superior.

Recommendations

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