This transcript has been edited for clarity.
I'm Dr Jeffrey Weber, a medical oncologist at the Laura and Isaac Perlmutter Cancer Center at NYU Langone Health here in New York City. I would like to report to you today on several abstracts presented at the recent ASCO meeting that was held virtually. Both were long-term updates of important, large trials that were conducted over the past couple of years.
The most important one, in my view, was the 6.5-year, very long–term follow-up on the CheckMate 067 trial, presented by Dr Jedd Wolchok from Memorial Sloan Kettering. This was a large randomized trial of ipilimumab/nivolumab (IPI/NIVO) vs NIVO alone vs IPI alone. The response rate continues to be impressive for the IPI/NIVO arm at 58%, with a 45% response rate for the arm that received NIVO alone, and of course much less, 19%, for IPI alone.
Progression-free survival at 6.5 years of follow-up was 34% for the combo and 29% for NIVO alone. The median overall survival was 72 months for IPI/NIVO, which is very impressive, vs a 36.9 months for NIVO alone and 19.9 months for IPI alone. There is clear superiority all the way along that curve, starting at about a year of follow-up.
COMMENTARY
New Long-term Data 'Clearly Favor' Combination Ipilimumab/Nivolumab in Melanoma
Jeffrey S. Weber, MD, PhD
DisclosuresAugust 03, 2021
This transcript has been edited for clarity.
I'm Dr Jeffrey Weber, a medical oncologist at the Laura and Isaac Perlmutter Cancer Center at NYU Langone Health here in New York City. I would like to report to you today on several abstracts presented at the recent ASCO meeting that was held virtually. Both were long-term updates of important, large trials that were conducted over the past couple of years.
The most important one, in my view, was the 6.5-year, very long–term follow-up on the CheckMate 067 trial, presented by Dr Jedd Wolchok from Memorial Sloan Kettering. This was a large randomized trial of ipilimumab/nivolumab (IPI/NIVO) vs NIVO alone vs IPI alone. The response rate continues to be impressive for the IPI/NIVO arm at 58%, with a 45% response rate for the arm that received NIVO alone, and of course much less, 19%, for IPI alone.
Progression-free survival at 6.5 years of follow-up was 34% for the combo and 29% for NIVO alone. The median overall survival was 72 months for IPI/NIVO, which is very impressive, vs a 36.9 months for NIVO alone and 19.9 months for IPI alone. There is clear superiority all the way along that curve, starting at about a year of follow-up.
Medscape Oncology © 2021 WebMD, LLC
Any views expressed above are the author's own and do not necessarily reflect the views of WebMD or Medscape.
Cite this: Jeffrey S. Weber. New Long-term Data 'Clearly Favor' Combination Ipilimumab/Nivolumab in Melanoma - Medscape - Aug 03, 2021.
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Authors and Disclosures
Authors and Disclosures
Author(s)
Jeffrey S. Weber, MD, PhD
Professor of Medicine, Deputy Director, Laura and Isaac Perlmutter Cancer Center, NYU Langone Medical Center, New York, NY
Disclosure: Jeffrey S. Weber, MD, PhD, has disclosed the following relevant financial relationships:
Serve(d) as a director, officer, partner, employee, advisor, consultant, or trustee for: Bristol-Myers Squibb Company; GlaxoSmithKline; Genentech BioOncology; Merck & Co., Inc.; Novartis Pharmaceuticals Corporation; EMD Serono, Inc.; Celldex Therapeutics; CytomX Therapeutics; Nektar Therapeutics; Roche; Altor BioScience Corporation; Daiichi-Sankyo ; Eli Lilly & Company
Received income in an amount equal to or greater than $250 from: Bristol-Myers Squibb Company; GlaxoSmithKline; Genentech BioOncology; Merck & Co., Inc.; Novartis Pharmaceuticals Corporation; EMD Serono, Inc.; Celldex Therapeutics; CytomX Therapeutics; Nektar Therapeutics; Roche; Altor BioScience Corporation; Daiichi-Sankyo; Eli Lilly & Company
Patent: Named on a patent filed by Moffitt for a biomarker for ipilimumab; named on a patent filed by Biodesix for a biomarker for nivolumab