Abstract and Introduction
Abstract
Zika virus diagnostic testing and laboratory research increased considerably when Zika virus began spreading through the Americas in 2015, increasing the risk for potential Zika virus exposure of laboratory workers and biomedical researchers. We report 4 cases of laboratory-associated Zika virus disease in the United States during 2016–2019. Of these, 2 were associated with needlestick injuries; for the other 2 cases, the route of transmission was undetermined. In laboratories in which work with Zika virus is performed, good laboratory biosafety practices must be implemented and practiced to reduce the risk for infection among laboratory personnel.
Introduction
Zika virus is a flavivirus that was first isolated in 1947 from a rhesus macaque in the Zika Forest in Uganda. Zika virus is primarily transmitted to humans by infected mosquitoes, but other confirmed transmission modes include intrauterine, sexual, and intrapartum transmission, and probable modes include transmission through blood transfusion and breastfeeding.[1] Laboratory-associated infection also has been reported in a small number of cases; one of the earliest reports of human Zika virus infection was possibly laboratory-acquired.[2]A researcher was working in a Uganda laboratory in 1963 with Zika virus strains isolated from mosquitoes. After he experienced fever and rash, laboratory testing indicated Zika virus infection.
