This transcript has been edited for clarity.
Hello. This is Dr JoAnn Manson, professor of medicine at Harvard Medical School and Brigham and Women's Hospital in Boston, Massachusetts. I'd like to talk with you about our study with the Women's Health Initiative (WHI) on estrogen-alone therapy and health outcomes among women with and without bilateral oophorectomy. The study was recently published Annals of Internal Medicine[1] and included 10,000 women with prior hysterectomy who were aged 50-79 at the time of randomization.
In all of the reports from the WHI hormone therapy trial, there has never been a previous study where the estrogen results differed between women who had their ovaries surgically removed versus the women with conserved ovaries. When we looked at the overall cohort across all age groups, we found minimal differences between the women with oophorectomy and those with conserved ovaries. The findings tended to be neutral, null, with no significant increases or decreases in major health outcomes.
However, when we looked at the results stratified by age, there were major differences across age groups among the women with bilateral oophorectomy and minimal differences among the women with conserved ovaries. During the intervention phase of 7 years, there was a generally adverse global index effect of
Skill Checkup: A Woman With Increasing Abdominal Pain, Nausea, Vomiting, and Ascites
Premenopausal Bilateral Oophorectomy Linked to Later Cognitive Impairment
Salpingo-Oophorectomy
COMMENTARY
Estrogen Therapy After Oophorectomy: Age Matters!
JoAnn E. Manson, MD, DrPH
DisclosuresSeptember 10, 2019
This transcript has been edited for clarity.
Hello. This is Dr JoAnn Manson, professor of medicine at Harvard Medical School and Brigham and Women's Hospital in Boston, Massachusetts. I'd like to talk with you about our study with the Women's Health Initiative (WHI) on estrogen-alone therapy and health outcomes among women with and without bilateral oophorectomy. The study was recently published Annals of Internal Medicine[1] and included 10,000 women with prior hysterectomy who were aged 50-79 at the time of randomization.
In all of the reports from the WHI hormone therapy trial, there has never been a previous study where the estrogen results differed between women who had their ovaries surgically removed versus the women with conserved ovaries. When we looked at the overall cohort across all age groups, we found minimal differences between the women with oophorectomy and those with conserved ovaries. The findings tended to be neutral, null, with no significant increases or decreases in major health outcomes.
However, when we looked at the results stratified by age, there were major differences across age groups among the women with bilateral oophorectomy and minimal differences among the women with conserved ovaries. During the intervention phase of 7 years, there was a generally adverse global index effect of
Medscape Ob/Gyn © 2019 WebMD, LLC
Any views expressed above are the author's own and do not necessarily reflect the views of WebMD or Medscape.
Cite this: JoAnn E. Manson. Estrogen Therapy After Oophorectomy: Age Matters! - Medscape - Sep 10, 2019.
Tables
References
Authors and Disclosures
Authors and Disclosures
Author(s)
JoAnn E. Manson, MD, DrPH
Professor of Medicine and the Michael and Lee Bell Professor of Women's Health, Harvard Medical School; Chief, Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts; Past President, North American Menopause Society, 2011-2012
Disclosure: JoAnn E. Manson, MD, DrPH, has disclosed no relevant financial relationships.