A Precision Medicine Approach to Alzheimer Risk Reduction

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A Precision Medicine Approach to Alzheimer Risk Reduction

Richard S. Isaacson, MD

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December 03, 2018

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Hi. I'm Dr Richard Isaacson, director of the Alzheimer's Prevention Clinic at Weill Cornell Medicine and NewYork-Presbyterian. I'm excited to talk today about a new article in Alzheimer's and Dementia, which is the journal of the Alzheimer's Association.

The article is titled, "The clinical practice of risk reduction for Alzheimer's disease: a precision medicine approach."[1] This article underscores what clinicians can do today, in an evidence-based and structured way, to help patients reduce their risk tomorrow. This is a paper that describes the clinical approach at the Alzheimer's Prevention Clinic at Weill Cornell and at the Alzheimer's Prevention Clinic & Research Center of Puerto Rico in San Juan.

This article goes through the ABCs of Alzheimer prevention management, which describe a way for clinicians to evaluate a patient, assess a patient's risk, and then give a patient a personalized plan for risk reduction. The A is for anthropometrics, the B is for blood-based biomarkers, and the C is for cognitive performance. The key here is for any clinician to try to give someone an evidence-based approach. There is no magic pill or magic potion to prevent or cure Alzheimer disease, and until a blockbuster drug comes, clinicians are struggling to figure out what can be done today.

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