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Tumor Genomic Profiling Practices and Perceptions
A survey of physicians provides insight into tumor profiling practices and the factors associated with genomic profiling study participation.
January 01, 2021
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Implications of Incidental Germline Findings Identified In the Context of Clinical Whole Exome Sequencing for Guiding Cancer Therapy
Could the identification of incidental germline mutations provide cancer risk information and help guide treatment decisions?
December 18, 2020
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Mutation Rates in Cancer Susceptibility Genes in Patients With Breast Cancer With Multiple Primary Cancers
The findings from this study further support the need for multigene panel testing in patients with breast cancer and other primary cancers.
October 09, 2020
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Genomic Profiles of De Novo High- and Low-Volume Metastatic Prostate Cancer
A better understanding of the genomic profiles of de novo metastatic prostate cancer could help inform future trial designs.
September 15, 2020
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Oncologist Confidence in Genomic Testing and Implications for Using Multimarker Tumor Panel Tests in Practice
How do oncologists feel about genomic testing and how likely are they to incorporate it into practice?
August 13, 2020
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Response of Brain Metastases From PIK3CA-Mutant Breast Cancer to Alpelisib
Is the newly approved PI3K-inhibitor alpelisib a safe and effective option for breast cancer patients with brain metastases? A case series provides insight into the treatment response.
July 30, 2020
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Targeting HER2 Alterations in Non-Small-Cell Lung Cancer
A better understanding of the role of HER2 alterations in non-small cell lung cancer could aid in the development of more targeted therapies.
May 29, 2020
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Evaluating Web-Based Direct-to-Consumer Genetic Tests for Cancer Susceptibility
Genetic testing for cancer susceptibility is now widely available through direct-to consumer testing kits, but what do we currently know about the process?
May 21, 2020
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Precision Prevention: The Current State and Future of Genomically Guided Cancer Prevention
Where are we currently in regards to genomically guided cancer prevention, and what challenges might the future hold?
May 07, 2020
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Pathogenic Variants in Cancer Predisposition Genes and Prostate Cancer Risk in Men of African Ancestry
A new study finds that men of African ancestry who are carriers of pathogenic variants in DNA repair genes may be at higher risk for aggressive prostate cancer.
March 16, 2020
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Prospective Decision Analysis Study of Clinical Genomic Testing in Metastatic Breast Cancer
Find out how genomic testing can help steer treatment decisions in metastatic breast cancer.
February 19, 2020
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Genomic Profiling for KRAS, NRAS, BRAF, Microsatellite Instability, and Mismatch Repair Deficiency Among Patients With Metastatic Colon Cancer
Genomic testing can identify biomarkers that may help guide treatment decisions in metastatic colon cancer, but are patients receiving these tests according to recommended guidelines?
February 06, 2020
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Next-Generation Sequencing and the Clinical Oncology Workflow
Technological challenges limit successful integration of genomic data into the electronic health record. Solutions, such as ASCO CancerLinQ, are discussed here.
December 11, 2019
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Predicting Expected Absolute Chemotherapy Treatment Benefit in Women With Early-Stage Breast Cancer Using EndoPredict, an Integrated 12-Gene Clinicomolecular Assay
Can a clinicomolecular score reliably predict absolute benefit of chemotherapy in women with HER2-negative, ER-positive breast cancer?
December 04, 2019
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Identifcation of Actionable Genomic Alterations Using Circulating Cell-Free DNA
Testing with cell-free DNA finds that over one-third of patients with advanced cancer have one or more actionable alterations.
November 27, 2019
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Comparative Analysis of Public Knowledge Bases for Precision Oncology
Because knowledge bases on gene-drug associations have considerable differences, clinicians should use more than one when seeking comprehensive information.
September 12, 2019
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Hodgkin Lymphoma and Cutaneous T-Cell Lymphoma Sharing the PCM1-JAK2 Fusion and a Common T-Cell Clone
Genomic profiling may help diagnose Hodgkin lymphoma in patients who exhibit signs of an associated CTCL but lack B-lineage markers.
August 29, 2019
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Concordance of Genomic Variants in Matched Primary Breast Cancer, Metastatic Tumor, and Circulating Tumor DNA
Biopsies from metastatic tumor and plasma ctDNA contain genomic variants not present in the primary tumor. More reason that ctDNA may be useful for therapy selection in breast cancer?
August 15, 2019
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Precision Oncology in Sarcomas
How is next-generation sequencing changing the landscape of diagnosis and treatment of sarcoma?
June 12, 2019
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Does Testing Error Underlie Liquid Biopsy Discordance?
False-positive and false-negative results with plasma next-generation sequencing are very concerning. Why do they occur and what should be done?
May 08, 2019
