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HbA1c Below the Reportable Range
This case report highlights the limitations of using HbA1c as a diagnostic tool in patients with certain conditions, including, as in this patient, hemolytic anemia.
April 29, 2022
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SARS-CoV-2 Antibody Testing: Where Are We Now?
This paper summarizes the current state of antibody testing for SARS-CoV2. What antibody tests are available, what are their limitations, and how should--and shouldn't--they be used?
March 29, 2022
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A Persistent Positive Antibody Test in a Patient With No History of COVID-19 Infection
This cases highlights the complexity of interpreting antibody test results and potential pitfalls of using antibody testing for the diagnosis of COVID-19.
February 21, 2022
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A Fluorescence-Based Quantitative Analysis for Total Bilirubin in Blood and Urine
The authors developed a novel, highly sensitive method to assess total bilirubin levels in serum and urine.
February 07, 2022
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Liver Blood Tests in the Management of Suspected Choledocholithiasis
The authors developed a mathematical model based on liver blood test values and their trend over 48 hours to predict the presence of common bile duct stones.
December 24, 2021
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Pancreatic Cancer Insights: Optimization of the Diagnostic Capacity of Tumor Biomarkers
Is the serum CA19.9/CEA ratio useful as a diagnostic tool for the differentiation of pancreatic cancer from benign pathology such as cirrhosis, pancreatitis, cholangitis, or choledocolithiasis?
November 24, 2021
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Sky High or Undetectable? A Patient With Discordant Hemoglobin A1c
What could possibly explain this patient's implausible HbA1c level of 54.6%, as measured by HPLC, especially considering her glucose level was 106 mg/dL?
October 21, 2021
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Clinical Utility of Midregional Proadrenomedullin in Patients With COVID-19
Might midregional proadrenomedullin, which has proven useful as a biomarker of organ failure, be a useful prognostic biomarker of in-hospital mortality in patients with COVID-19?
September 23, 2021
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Laboratory Predictors of COVID-19 Pneumonia in Patients With Mild to Moderate Symptoms
The authors developed a laboratory model that can accurately distinguish mild-to-moderately symptomatic COVID-19 patients with pneumonia from those without pneumonia.
August 23, 2021
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Initial Clinical Laboratory Response to COVID-19
This study surveyed laboratory professionals about their needs and experiences at the onset of the COVID-19 pandemic. What did they learn?
July 23, 2021
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Evaluation of HCV RNA by PCR and Signal-to-Cutoff Ratios of HCV Antibody Assays for Diagnosis of HCV Infection
This study investigated whether HCV infection can be diagnosed correctly with an anti-HCV antibody test and an HCV RNA test without the addition of a recombinant immunoblot assay.
June 28, 2021
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Comparison of Serum Free and Bioavailable 25-Hydroxyvitamin D Levels in Alzheimer's Disease and Healthy Control Patients
Might reduced levels of the active free form of vitamin D be a risk factor for Alzheimer disease and dementia?
May 27, 2021
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How Reliable Is Automated Urinalysis in Acute Kidney Injury?
This study evaluated the role of automated urinalysis in predicting acute kidney injury. How did its reliability compare with manual microscopy?
May 03, 2021
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Neurogranin as a Novel Biomarker in Alzheimer's Disease
This study evaluated the diagnostic value of CSF neurogranin and alpha-synuclein as biomarkers of synapsis damage in patients with Alzheimer disease.
April 26, 2021
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Machine Learning Prediction of SARS-CoV-2 Polymerase Chain Reaction Results With Routine Blood Tests
Can machine learning methods reliably predict a negative SARS-CoV-2 RT-PCR test result using standard blood tests?
April 19, 2021
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Absolute Lymphocytes, Ferritin, C-Reactive Protein, and Lactate Dehydrogenase Predict Early Invasive Ventilation in Patients With COVID-19
This study identified several laboratory parameters that, in combination with ferritin, may help to predict the need for mechanical invasive ventilation within the first 48 hours.
April 12, 2021
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CRISPR-Based Approaches for Efficient and Accurate Detection of SARS-CoV-2
Might CRISPR-based approaches be viable alternatives to conventional RT-PCR methods for the efficient and accurate detection of SARS-CoV-2?
April 05, 2021
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Impact of Pool Testing in Detection of Asymptomatic Patients With COVID-19
This study explored the impact of dilution on the detectability of SARS-CoV-2 in asymptomatic patients using RT-PCR.
February 24, 2021
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The Association Between Serum Leptin Levels and Cardiovascular Events in Patients With Rheumatoid Arthritis
Might elevated serum leptin levels be a prognostic biomarker for predicting cardiovascular complications in patients with rheumatoid arthritis?
February 17, 2021
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Mesenchymal Stem Cells in COVID-19
Might mesenchymal stem cells have a therapeutic role in critically ill patients suffering from COVID-19? This paper looks at the current state of research.
February 10, 2021
